Directed by Gene Saks, Wealthy, eccentric Mame is living it up during the Roaring 20′s when she becomes guardian to her late brother’s little boy Patrick. She embraces the new role with typical enthusiasm, showing her charge how to live to the fullest, filling his life with culture, adventure, and fun. Mame and Patrick go through good times and bad during his childhood. But when he returns home from college and Mame in introduced to his stuffy fiance and bigoted parents, she faces her greatest challenge. With some help from her dearest friend, Vera, she helps keep things at 3 Beekman Place a rousing free-for-all.