Directed by Virginie Despentes and Coralie, Manu has lived a difficult life. Abused and violently raped, she sets off to find herself only to meet Nadine, a prostitute who has encountered one too many injustices in the world. Angry at the world, they embark on a twisted, rage-filled road trip. They choose to have sex when they please and kill when they need. Leaving a trail of mischief and dead bodies, in a media blitz and man hunt, soon everyone is out to capture the young fugitives.